Events in the last years have shown us that we remain vulnerable to sudden outbreaks of previously unknown or forgotten zoonotic pathogens. Since we met in Kansas, USA in May 2017, we witnessed the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for the current global pandemic. Since first reported in December 2019, over 98 million human cases and 2 million deaths have officially been reported thus far. In addition, Ebola re-emerged twice causing epidemics in the Democratic Republic of the Congo. Highly pathogenic avian influenza viruses continue to emerge throughout the world, challenging public and animal health systems. As African Swine Fever virus (ASFV) continues to spread across Southeast Asia, Classical Swine Fever virus (CSFV) reports occur in Japan, and Foot and Mouth Disease virus (FMDV) spread continues with new strains emerging, there is increased concern that these diseases will spread to developed countries and devastate their economies. There is a significantly raised awareness that zoonoses and transboundary diseases threaten both human and animal health. Therefore, research and policy must focus on a "One Health" perspective in local, national, and international environments. In order to properly address these issues in our conference we plan to have workshops which will be organized by experts in their fields.