We are looking forward to welcoming you back to Geneva, Switzerland, for the 6th International Conference on Prevention and Infection Control (ICPIC), which will be held on 14-17 September 2021. After the challenging past year through the COVID-19 pandemic, the need to bring together the global IPC community becomes even stronger. We believe that all required conditions will be met next September to be able to organize a safe, interactive and stimulating face-to-face conference. The conference will again offer a unique forum for participants to exchange knowledge and experience in the prevention of healthcare-associated infections and control of antimicrobial resistance around the world. Conscious of the challenges for some colleagues from overseas to travel to Geneva, there will be an opportunity to also connect with us virtually for selected sessions. The most resonating topics will be addressed including: IPC in the context of the COVID-19 pandemic, antimicrobial resistance, catheter-related bloodstream infection, quality of patient care, advanced methods in hospital epidemiology research and early results of major clinical trials in the field, improving prevention strategies using various implementation tools as well as social media, telemedicine, and simulation models.