2nd International Conference on Sustainable Expert Systems [ICSES 2021] is a refereed conference with a primary focus on the research information related to Artificial Intelligence [AI], Sustainability, and Expert Systems applied in almost all the areas of industries, government sectors, and educational institutions worldwide. The main thrust of the conference is to publish the papers that deal with the design, implementation, development, testing, and management of intelligent and sustainable expert systems and also to provide both theoretical and practical guidelines for the deployment of these systems. ICSES 2021 will provide an opportunity for the researchers to present their research results and examine the advanced applications in Artificial Intelligence [AI] and the expert systems field. The advanced research discussions in ICSES 2021 will facilitate new research pathways and drive innovations in the sustainable expert systems domain. This conference aims to collect recent advances in the research and development of sustainable expert systems with a particular focus on their significant role in elevating the innovations in Artificial intelligence.