The conference will bring together scientists working to better understand three-dimensional genome organization in various organisms, tissues, and cell states. Conference sessions will include: - Structure and function of subnuclear domains - Topogically Associated Domains (TADs) and similar domains - Signalling cues, cellular states and genome organization - DNA damage and spatial genome organization - Genome structure in health and disease - Workshop I: Genome editing and super-resolution microscopy - Workshop II: Chromosome conformation capture, sequencing and databases - Workshop III: Young scientists in the era of spatial genome organization, how to get published? Learning Objectives The conference has three main learning objectives. First, we will aim to clarify the factors and principles guiding the organization of the genome into domains and compartments and how this impacts genome expression and stability. Second, we will aim to better understand how and why genome structures are altered by signalling cues and cellular states. Third, we wish to clarify how the disruption of spatial genome organization contributes to pathobiology and disease. Target Audience This conference should be of interest to individuals seeking to understand the basic principles of spatial genome organization and how the disruption of this organization impacts health and disease.