A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signalling pathways involved are evolutionarily conserved, and are starting to be implicated in human aging. This raises the intriguing possibility of performing preventative medicine against the chronic diseases of our time by targeting the main risk factor for all of them, namely aging. Two important current challenges in the field are (1) to understand the downstream pathways by which longevity interventions combat age-related loss of function and pathology, and (2) to translate the findings into the extension of human healthspan. This third meeting will continue to explore these topics, with particular emphasis on the systemic environment, mitochondria, biomarkers and frailty, immune aging and the protective effects of natural products. Learning Objectives - Identify and understand translational approaches to extend human healthspan - Understand emergent areas of research in aging - Obtain an advanced view on the molecular biology and genetics of aging - Understand for profit approaches to mitigate human aging Target Audience - Basic scientists in the field of aging research using animal models. - Human researchers interested in biomarkers of aging - Clinical trials specialists in aging and associated diseases. - Scientists and other professionals developing aging interventions.